INTERSTITIAL PULMONARY FIBROSIS

Familial Interstitial Pulmonary Fibrosis.

In 1944 Hamman and Rich first described a disease that caused an acute diffuse interstitial fibrosis of the lungs, and which resulted in the death of four patients within six months of the onset of symptoms. Since then countless further cases have been reported in the literature, and our knowledge of the subject has advanced. It is recognized that the interstitial fibrotic process may be locali...

Interstitial pulmonary fibrosis.

The study of animal models of IPF has demonstrated that there is a stereotyped response of the respiratory airspace walls to a wide variety of injuries. Inflammatory and immune effector cells play a major and complex role in the fibrosing process. They may contribute to the injury of the lung beyond the original insult. These cells secrete substances that play an important role in determining c...

Auto-antibody Studies in Interstitial Pulmonary Fibrosis.

Diffuse interstitial pulmonary fibrosis and rheumatoid arthritis.

Diffuse interstitial pulmonary fibrosis in rheumatoid arthritis has received considerable attention since it was first described 20 years ago (Ellman and Ball, 1948). It appears that few authorities now doubt that the association is valid, despite the absence of statistical evidence from controlled investigations (Aronoff, Bywaters, and Fearnley, 1955; Talbott and Calkins, 1964; Stack and Grant...

Diffuse interstitial pulmonary fibrosis with recovery.

Since 1944, when Hamman and Rich published their third paper on diffuse interstitial pulmonary fibrosis, details of many cases have been recorded: the subject has recently been reviewed by Living-stone, Lewis, Reid, and Jefferson (1964). There are, however, comparatively few reports of the occurrence of the syndrome in childhood. Cases in children, with histological verification, have been The ...